*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
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The study involved 208 people who had, or were at high risk of developing, coronary artery disease and were being treated with a statin drug (primarily simvastatin [Zocor] or atorvastatin [Lipitor]). Participants were randomly assigned to receive niacin or a second cholesterol-lowering drug (ezetimibe; brand name Zetia) for an average of 14 months. Niacin was taken in the form of extended-release tablets at bedtime. The initial dose was 500 mg, which was increased as tolerated to a maximum of 2,000 mg each night.
In this study, niacin was well tolerated by most participants. However, niacin frequently causes a skin flush, which some people find intolerable, and 18% of the participants taking niacin discontinued it because of side effects.
On rare occasions, niacin in large doses (particularly extended-release forms of niacin) has caused liver damage. It is therefore important for anyone taking a large amount of niacin (such as more than 500 mg per day) to be monitored by a doctor. Despite these potential adverse effects, niacin has been shown to be an important weapon in the battle against cardiovascular disease.
Niacinamide, a form of vitamin B3 that is similar to niacin, does not cause a skin flush and does not lower serum cholesterol levels. Inositol hexanicotinate (sometimes called “no-flush niacin”) is another form that usually does not cause a skin flush. However, its effect on serum cholesterol levels appears to be minimal.
SUGGESTED USE: As a dietary supplement for adults, take one (1) vegetable capsule daily, preferably with a meal or as directed by a healthcare practitioner.
FREE OF: Gluten, Wheat, Dairy, Soy, Yeast, Sugar, Sodium, Artificial Flavor, Sweetener, Preservatives and Color.
Not intended for use by pregnant and nursing women. If you are taking any medications or have a medical condition, please consult your healthcare practitioner before taking any dietary supplement. Discontinue use and consult your healthcare practitioner if any adverse reactions occur. Keep out of reach of children. Store at room temperature. Do not use if outer bottle seal is missing or damaged.
NOTICE: Use of this product may cause temporary skin flushing (hot feeling and skin redness), burning, itching, or rash caused by an increase in blood flow near the skin. Sensitive individuals may experience an unexpected drop of blood pressure or dizziness. Do not take on an empty stomach. Do not take more than the recommended dose unless prescribed by your doctor.