NOW Phosphatidyl Serine 100mg (60 veg caps)

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Cognitive health, supports memory & brain function, promotes intercellular communication.
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Cognitive health, supports memory & brain function, promotes intercellular communication.



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Health Notes

Disclaimer: The following content is provided by Aisle7 and is for informational purposes only. It is based on scientific studies, clinical experience, or usage as cited in each article. Hi-Health provides this information as a service but does not endorse it. In addition, Aisle7 does not recommend or endorse any specific products.

Phosphatidylserine

Phosphatidylserine
This nutrient has been used in connection with the following health goals
  • Reliable and relatively consistent scientific data showing a substantial health benefit.
  • Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
  • For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary “Star-Rating” system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

This supplement has been used in connection with the following health conditions:

Age-Related Cognitive Decline
Dose: 300 mg daily of bovine-derived supplement
Bovine-derived PS (phosphatidylserine) has been shown to improve memory, cognition, and mood in the elderly. To date, most evidence suggests that soy-derived PS is not effective for ARCD. (more)
Alzheimer’s Disease
Dose: Refer to label instructions
There is some evidence that cow-derived PS (phosphatidylserine) has been shown to improve mental function and feelings of well-being in people with Alzheimer’s disease, though most research has not found benefit. (more)
Age-Related Cognitive Decline
Dose: 300 mg daily of bovine-derived supplement
Bovine-derived PS (phosphatidylserine) has been shown to improve memory, cognition, and mood in the elderly. To date, most evidence suggests that soy-derived PS is not effective for ARCD. (more)
Athletic Performance and Enhanced Endurance in Young Active Men
Dose: 750 mg daily
In a study of active young men, supplementation with phosphatidylserine increased the time the men could exercise until exhaustion by approximately 25%. (more)
Age-Related Cognitive Decline
Dose: 300 mg daily of bovine-derived supplement  

Phosphatidylserine (PS) derived from bovine brain phospholipids has been shown to improve memory, cognition, and mood in the elderly in at least two placebo-controlled trials. In both trials, geriatric patients received 300 mg per day of PS or placebo. In an unblinded trial of ten elderly women with depressive disorders, supplementation with PS produced consistent improvement in depressive symptoms, memory, and behavior after 30 days of treatment.1 A double-blind trial of 494 geriatric patients with cognitive impairment found that 300 mg per day of PS produced significant improvements in behavioral and cognitive parameters after three months and again after six months.2

Most research has been conducted with PS derived from bovine tissue, but what is available commercially is made from soy. The soy- and bovine-derived PS, however, are not structurally identical.3 Doctors and researchers have debated whether the structural differences could be important,4, 5 but so far only a few trials have studied the effects of soy-based PS.

Preliminary animal research shows that the soy-derived PS does have effects on brain function similar to effects from the bovine source.6, 7, 8 An isolated, unpublished double-blind human study used soy-derived PS in an evaluation of memory and mood benefits in nondemented, nondepressed elderly people with impaired memories and accompanying depression.9 In this three-month study, 300 mg per day of PS was not significantly more effective than a placebo. In a double-blind study, soy-derived PS was administered in the amount of 300 or 600 mg per day for 12 weeks to people with age-related memory impairment. Compared with the placebo, soy-derived PS had no effect on memory or on other measures of cognitive function.10 While additional research needs to be done, currently available evidence suggests that soy-derived PS is not an effective treatment for age-related cognitive decline.

References

1. Maggioni M, Picotti GB, Bondiolotti GP, et al. Effects of phosphatidylserine therapy in geriatric patients with depressive disorders. Acta Psychiatr Scand 1990;81(3):265-70.

2. Cenacchi T, Bertoldin T, Farina C, et al. Cognitive decline in the elderly: a double-blind, placebo-controlled multicenter study on efficacy of phosphatidylserine administration. Aging (Milano) 1993;5(2):123-33.

3. Sakai M, Yamatoya H, Kudo S. Pharmacological effects of phosphatidylserine enzymatically synthesized from soybean lecithin on brain functions in rodents. J Nutr Sci Vitaminol (Tokyo) 1996;42:47-54.

4. Kidd PM. Don't believe everything you read. . .a sequel. Point. Townsend Letter for Doctors Patients 1997;July:122-4 [editorial].

5. Gaby AR. Don't believe everything you read. CounterPoint. Townsend Letter for Doctors Patients 1997;July:125-6 [editorial].

6. Furushiro M, Suzuki S, Shishido Y, et al. Effects of oral administration of soybean lecithin transphosphatidylated phosphatidylserine on impaired learning of passive avoidance in mice. Jpn J Pharmacol 1997;75:447-50.

7. Sakai M, Yamatoya H, Kudo S. Pharmacological effects of phosphatidylserine enzymatically synthesized from soybean lecithin on brain functions in rodents. J Nutr Sci Vitaminol (Tokyo) 1996;42:47-54.

8. Blokland A, Honig W, Brouns F, et al. Cognition-enhancing properties of subchronic phosphatidylserine (PS) treatment in middle-aged rats: comparison of bovine cortex PS with egg PS and soybean PS. Nutrition 1999;15:778-83.

9. Gindin J, Novikov M, Kedar D, et al. The effect of plant phosphatidylserine on age-associated memory impairment and mood in the functioning elderly. Rehovot, Israel: Geriatric Institute for Education and Research, and Department of Geriatrics, Kaplan Hospital, 1995.

10. Jorissen BL, Brouns F, Van Boxtel MPJ, et al. The influence of soy-derived phosphatidylserine on cognition in age-associated memory impairment. Nutr Neurosci 2001;4:121-34.

Alzheimer’s Disease
Dose: Refer to label instructions  

Phosphatidylserine (PS), which is related to lecithin, is a naturally occurring compound present in the brain. Although it is not a cure, 100 mg of PS taken three times per day has been shown to improve mental function, such as the ability to remember names and to recall the location of frequently misplaced objects, in people with Alzheimer’s disease.1 However, subsequent studies have not validated these results. In one double-blind trial, only the most seriously impaired participants received benefits from taking PS; people with moderate Alzheimer’s disease did not experience significant improvements in cognitive function.2 In another double-blind trial, people with Alzheimer’s disease who took 300 mg of PS per day for eight weeks had better improvement in overall well-being than those who took placebo, but there were no significant differences in mental function tests.3 In another double-blind trial, 200 mg of PS taken twice daily produced short-term improvements in mental function (after six to eight weeks), but these effects faded toward the end of the six-month study period.4

The PS used in these studies was obtained from bovine brain phospholipids. A plant source of PS is also available. However, the chemical structure of the plant form of PS differs from the bovine form. In a preliminary study, plant-derived PS was no more effective than a placebo at improving the memory of elderly people.5 Soy-derived PS was also ineffective in a double-blind study of elderly people with age-related cognitive decline.6

References

1. Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6.

2. Amaducci L. Phosphatidylserine in the treatment of Alzheimer's disease: results of a multicenter study. Psychopharmacol Bull 1988;24:130-4.

3. Engel RR, Satzger W, Gunther W, et al. Double-blind cross-over study of phosphatidylserine vs. placebo in patients with early dementia of the Alzheimer type. Eur Neuropsychopharmacol 1992;2:149-55.

4. Heiss WD, Kessler J, Mielke R, et al. Long-term effects of phosphatidylserine, pyritinol, and cognitive training in Alzheimer's disease. A neuropsychological, EEG, and PET investigation. Dementia 1994;5:88-98.

5. Gindin J, Novikov M, Kedar D, et al. The effect of plant phosphatidylserine on age-associated memory impairment and mood in the functioning elderly. Rehovot, Israel: Geriatric Institute for Education and Research, and Department of Geriatrics, Kaplan Hospital, 1995.

6. Jorissen BL, Brouns F, Van Boxtel MPJ, et al. The influence of soy-derived phosphatidylserine on cognition in age-associated memory impairment. Nutr Neurosci 2001;4:121-34.

Age-Related Cognitive Decline
Dose: 300 mg daily of bovine-derived supplement  

Phosphatidylserine (PS) derived from bovine brain phospholipids has been shown to improve memory, cognition, and mood in the elderly in at least two placebo-controlled trials. In both trials, geriatric patients received 300 mg per day of PS or placebo. In an unblinded trial of ten elderly women with depressive disorders, supplementation with PS produced consistent improvement in depressive symptoms, memory, and behavior after 30 days of treatment.1 A double-blind trial of 494 geriatric patients with cognitive impairment found that 300 mg per day of PS produced significant improvements in behavioral and cognitive parameters after three months and again after six months.2

Most research has been conducted with PS derived from bovine tissue, but what is available commercially is made from soy. The soy- and bovine-derived PS, however, are not structurally identical.3 Doctors and researchers have debated whether the structural differences could be important,4, 5 but so far only a few trials have studied the effects of soy-based PS.

Preliminary animal research shows that the soy-derived PS does have effects on brain function similar to effects from the bovine source.6, 7, 8 An isolated, unpublished double-blind human study used soy-derived PS in an evaluation of memory and mood benefits in nondemented, nondepressed elderly people with impaired memories and accompanying depression.9 In this three-month study, 300 mg per day of PS was not significantly more effective than a placebo. In a double-blind study, soy-derived PS was administered in the amount of 300 or 600 mg per day for 12 weeks to people with age-related memory impairment. Compared with the placebo, soy-derived PS had no effect on memory or on other measures of cognitive function.10 While additional research needs to be done, currently available evidence suggests that soy-derived PS is not an effective treatment for age-related cognitive decline.

References

1. Maggioni M, Picotti GB, Bondiolotti GP, et al. Effects of phosphatidylserine therapy in geriatric patients with depressive disorders. Acta Psychiatr Scand 1990;81(3):265-70.

2. Cenacchi T, Bertoldin T, Farina C, et al. Cognitive decline in the elderly: a double-blind, placebo-controlled multicenter study on efficacy of phosphatidylserine administration. Aging (Milano) 1993;5(2):123-33.

3. Sakai M, Yamatoya H, Kudo S. Pharmacological effects of phosphatidylserine enzymatically synthesized from soybean lecithin on brain functions in rodents. J Nutr Sci Vitaminol (Tokyo) 1996;42:47-54.

4. Kidd PM. Don't believe everything you read. . .a sequel. Point. Townsend Letter for Doctors Patients 1997;July:122-4 [editorial].

5. Gaby AR. Don't believe everything you read. CounterPoint. Townsend Letter for Doctors Patients 1997;July:125-6 [editorial].

6. Furushiro M, Suzuki S, Shishido Y, et al. Effects of oral administration of soybean lecithin transphosphatidylated phosphatidylserine on impaired learning of passive avoidance in mice. Jpn J Pharmacol 1997;75:447-50.

7. Sakai M, Yamatoya H, Kudo S. Pharmacological effects of phosphatidylserine enzymatically synthesized from soybean lecithin on brain functions in rodents. J Nutr Sci Vitaminol (Tokyo) 1996;42:47-54.

8. Blokland A, Honig W, Brouns F, et al. Cognition-enhancing properties of subchronic phosphatidylserine (PS) treatment in middle-aged rats: comparison of bovine cortex PS with egg PS and soybean PS. Nutrition 1999;15:778-83.

9. Gindin J, Novikov M, Kedar D, et al. The effect of plant phosphatidylserine on age-associated memory impairment and mood in the functioning elderly. Rehovot, Israel: Geriatric Institute for Education and Research, and Department of Geriatrics, Kaplan Hospital, 1995.

10. Jorissen BL, Brouns F, Van Boxtel MPJ, et al. The influence of soy-derived phosphatidylserine on cognition in age-associated memory impairment. Nutr Neurosci 2001;4:121-34.

Athletic Performance and Enhanced Endurance in Young Active Men
Dose: 750 mg daily In a double-blind study of active young men, supplementation with 750 of soybean-derived phosphatidylserine per day for 10 days increased the time the men could exercise until exhaustion by approximately 25%.1 Longer studies are needed to determine whether this effect would persist with continued supplementation.
References

1. Kingsley MI, Miller M, Kilduff LP, et al. Effects of phosphatidylserine on exercise capacity during cycling in active males. Med Sci Sports Exerc 2006;38:64­-71.

Phosphatidylserine (PS) belongs to a special category of fat-soluble substances called phospholipids, which are essential components of cell membranes. PS is found in high concentrations in the brain.

Copyright © 2017 Healthnotes, Inc. All rights reserved. www.healthnotes.com

Learn more about Healthnotes, the company.

The information presented by Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2017.

Supplemental Facts

Ingredients


Supplement Facts
Serving Size: 1 Vcap®
Amount Per Serving %DV
Phosphatidyl Serine (from soy) 100 mg *
Choline (from Choline Bitartrate) 100 mg *
Inositol 50 mg *
*Daily Values are based on a 2,000 calorie diet.
**Daily Value (DV) not established.

Other Ingredients: Cellulose, Cellulose (capsule) and Silica.

Contains no: sugar, salt, starch, yeast, wheat, gluten, milk, egg, shellfish or preservatives. Vegetarian/Vegan Product.


The most accurate information is always on the label on the actual product. While we periodically update our website, the values on the website are intended to be a general guide to consumers. For absolute values, the actual label on the product at hand should be relied on.

Additional Information

Additional Info


As a dietary supplement, take 1 Vcap® 1 to 3 times daily, preferably with food. Consider taking this product in combination with Ginkgo Biloba and DMAE.


Do not eat freshness packet. Keep in bottle. Natural color variations may occur in this product. Store in a cool, dry place. Please Recycle.


Vcaps® is a registered trademark of Capsugel.

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