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In this study, 76 healthy men and women (ages 48 to 90) who had at least four actinic keratoses were randomly assigned to receive 500 mg of niacinamide once daily or twice daily, or placebo for four months. All participants had skin examinations before the study and at two and four months.
Results showed that both niacinamide groups had about one-third fewer actinic keratoses at four months compared with the control group. The niacinamide group also had a lower risk of developing a new skin cancer lesion during the study period compared with the control group (11 placebo participants developed 20 new skin cancers and 2 niacinamide participants developed 4 cancers).
It isn’t exactly clear how niacinamide may help prevent lesions that may lead to skin cancer, but the study authors comment that niacinamide may help repair damaged DNA and help boost our immune system. They report that niacinamide is “highly immune protective in humans” and has been shown to prevent cancer in mice. Further research is needed about dosages and safety. Higher doses of niacinamide than those used in this study have been linked to a risk of liver damage.
Always talk with a doctor before starting a supplement to understand more about the risks and benefits.
Skin cancer is a common type of cancer, but the good news is that there are things we can do to help prevent them. Experts recommend these and other steps for protecting your skin:
(J Invest Dermatol 2012;132:1497–500)
Cautions: For external use only. Do not apply to broken or irritated skin. If sensitivity occurs discontinue use.